Of all the many ways the teeming ecosystem of microbes in a person’s gut and other tissues might affect health, its potential influences on the brain may be the most provocative. Now, a study of two large groups of Europeans has found several species of gut bacteria are missing in people with depression. The researchers can’t say whether the absence is a cause or an effect of the illness, but they showed that many gut bacteria could make substances that affect nerve cell function—and maybe mood.
“It’s the first real stab at tracking how” a microbe’s chemicals might affect mood in humans, says John Cryan, a neuroscientist at University College Cork in Ireland who has been one of the most vocal proponents of a microbiome-brain connection. The study “really pushes the field from where it’s been” with small studies of depressed people or animal experiments. Interventions based on the gut microbiome are now under investigation: The University of Basel in Switzerland, for example, is planning a trial of fecal transplants, which can restore or alter the gut microbiome, in depressed people.
Several studies in mice had indicated that gut microbes can affect behavior, and small studies of people suggested this microbial repertoire is altered in depression. To test the link in a larger group, Jeroen Raes, a microbiologist at the Catholic University of Leuven in Belgium, and his colleagues took a closer look at 1054 Belgians they had recruited to assess a “normal” microbiome. Some in the group—173 in total—had been diagnosed with depression or had done poorly on a quality of life survey, and the team compared their microbiomes with those other participants. Two kinds of microbes, Coprococcus and Dialister, were missing from the microbiomes of the depressed subjects, but not from those with a high quality of life. The finding held up when the researchers allowed for factors such as age, sex, or antidepressant use, all of which influence the microbiome, the team reports today in Nature Microbiology. They also found the depressed people had an increase in bacteria implicated in Crohn disease, suggesting inflammation may be at fault. [Continue reading…]