Attention to the Unseen

Viviane Callier writes: Aging can seem like an unregulated process: As time marches along, our cells and bodies inevitably accumulate dings and dents that cause dysfunctions, failures and ultimately death. However, in 1993 a discovery upended that interpretation of events. Researchers found a mutation in a single gene that doubled a worm’s life span; subsequent work showed that related genes, all involved in the response to insulin, are key regulators of aging in a host of animals, from worms and…

Read More Read More

Science reports: This week, thousands of researchers are flocking to downtown Philadelphia for what’s billed as the largest international conference dedicated to Alzheimer’s disease. But several kilometers away a much smaller group congregated for an alternative meetup: a daylong dive into whether and how pathogens might cause the fatal dementia. Saturday’s gathering of about 80 scientists on the city’s periphery is something of a metaphor for where the idea sits in the larger Alzheimer’s community, long dominated by the view…

Read More Read More

Nature reports: Antibodies isolated from people with long COVID increase pain sensitivity and reduce movement in mice when transferred to the animals, research shows. The findings suggest that antibodies might drive some symptoms of long COVID — although how that process works is unclear, and the results will need to be replicated in larger studies. “I think this will be a beacon of a paper that we can take forwards to further understand long COVID,” says Resia Pretorius, an immunologist…

Read More Read More