Attention to the Unseen

Science Alert reports: Lower temperatures might not warm your heart, but they could make for a longer life. Past research has proposed a few reasons behind this intriguing phenomenon. Now scientists from the University of Cologne in Germany have used experiments on worms to identify another possible reason: coldness drives a process through which damaged proteins are removed from cells. Several neurodegenerative diseases that can take hold as we get older – including Alzheimer’s and Parkinson’s – are linked to…

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Science Alert reports: Tensions between the brain, the gut, and the makeup of its microbial inhabitants appear to play a critical role in the development of neurodegenerative conditions. While evidence favoring a link between the microbiota-gut-brain axis (MGBA) and Alzheimer’s disease continues to grow, the exact mechanism behind the relationship is still poorly understood. The puzzle pieces have so far been frustratingly incoherent, involving seemingly unrelated factors as tangled proteins inside nervous tissue to suspect gut microbes to subtle differences…

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Yasemin Saplakoglu writes: Our bodies consist of about 30 trillion human cells, but they also host about 39 trillion microbial cells. These teeming communities of bacteria, viruses, protozoa and fungi in our guts, in our mouths, on our skin and elsewhere — collectively called the human microbiome — don’t only consist of freeloaders and lurking pathogens. Instead, as scientists increasingly appreciate, these microbes form ecosystems essential to our health. A growing body of research aims to understand how disruptions of…

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Nature reports: The emergence of disease-causing bacteria that are resistant to antibiotics is often attributed to the overuse of antibiotics in people and livestock. But researchers have homed in on another potential driver of resistance: antidepressants. By studying bacteria grown in the laboratory, a team has now tracked how antidepressants can trigger drug resistance1. “Even after a few days exposure, bacteria develop drug resistance, not only against one but multiple antibiotics,” says senior author Jianhua Guo, who works at the…

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Nature reports: Most studies on how humans acquire their microbiomes have focused on people’s first contact with microbes: through their mums. “It’s key to providing a microbial starter kit,” says Hilary Browne, a microbiologist at the Wellcome Sanger Institute in Hinxton, UK. To examine how and why this starter kit changes over a person’s life, a team led by microbiome researchers Mireia Valles-Colomer and Nicola Segata at the University of Trento, Italy, analysed DNA from nearly 10,000 stool and saliva…

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