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Category: Science

New $3.2 billion program will support the development of drug to treat Covid-19

New $3.2 billion program will support the development of drug to treat Covid-19

The New York Times reports: The U.S. government spent more than $18 billion last year funding drugmakers to make a Covid vaccine, an effort that led to at least five highly effective shots in record time. Now it’s pouring more than $3 billion on a neglected area of research: developing pills to fight the virus early in the course of infection, potentially saving many lives in the years to come. The new program, announced on Thursday by the Department of…

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What Covid-19’s long tail is revealing about chronic disease

What Covid-19’s long tail is revealing about chronic disease

David Cox writes: One of the major challenges for doctors attempting to treat long Covid is that there are likely to be a variety of underlying triggers or causes, depending on the patient. Recent epidemics have provided one way of gaining crucial clues about what these underlying causes might be. Far from being unique to Sars-CoV-2 – the virus that causes Covid-19 – some scientists believe almost all infectious outbreaks leave behind a proportion of patients who remain chronically unwell…

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The FDA should be our toughest regulatory body, but the pharmaceutical lobby has torn it to shreds

The FDA should be our toughest regulatory body, but the pharmaceutical lobby has torn it to shreds

Natalie Shure writes: Last week the Food and Drug Administration approved Aduhelm—the first new Alzheimer’s drug in 18 years—an event that, at first blush, heralds the amazing news of a medical advance. Perhaps it might have been, had the whole process leading up to the agency giving its nod to the medication played out in a functional health care system. But that’s not what happened. Far from hailing the advent of a transformative breakthrough for the six million Americans suffering…

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When graphs are a matter of life and death

When graphs are a matter of life and death

Hannah Fry writes: In “A History of Data Visualization and Graphic Communication” (Harvard), Michael Friendly and Howard Wainer, a psychologist and a statistician, argue that visual thinking, by revealing what would otherwise remain invisible, has had a profound effect on the way we approach problems. The book begins with what might be the first statistical graph in history, devised by the Dutch cartographer Michael Florent van Langren in the sixteen-twenties. This was well into the Age of Discovery, and Europeans…

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Could a nasal spray of designer antibodies help to beat Covid?

Could a nasal spray of designer antibodies help to beat Covid?

Dr. Francis Collins writes: There are now several monoclonal antibodies, identical copies of a therapeutic antibody produced in large numbers, that are authorized for the treatment of COVID-19. But in the ongoing effort to beat this terrible pandemic, there’s plenty of room for continued improvements in treating infections with SARS-CoV-2, the virus that causes COVID-19. With this in mind, I’m pleased to share progress in the development of a specially engineered therapeutic antibody that could be delivered through a nasal…

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The implications of the lab-leak hypothesis

The implications of the lab-leak hypothesis

David Wallace-Wells writes: Nothing has changed but the narrative. A majority of Americans now believe that the coronavirus emerged from a lab, not nature, and in recent weeks a new openness to the lab-leak theory has taken over “nearly all mainstream media,” as my colleague Jonathan Chait put it. But the material case for the hypothesis remains essentially unchanged from the version advanced by Nicholson Baker, in this magazine, in January — indeed more or less unchanged from the version…

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Virologist, Shi Zhengli, at center of a pandemic storm, speaks out

Virologist, Shi Zhengli, at center of a pandemic storm, speaks out

The New York Times reports: To a growing chorus of American politicians and scientists, she is the key to whether the world will ever learn if the virus behind the devastating Covid-19 pandemic escaped from a Chinese lab. To the Chinese government and public, she is a hero of the country’s success in curbing the epidemic and a victim of malicious conspiracy theories. Shi Zhengli, a top Chinese virologist, is once again at the center of clashing narratives about her…

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Reports of severe Covid or death after vaccination are rare, but not unexpected

Reports of severe Covid or death after vaccination are rare, but not unexpected

The New York Times reports: Over the last few months, a steady drumbeat of headlines has highlighted the astounding real-world effectiveness of the Covid-19 vaccines, especially the mRNA vaccines made by Pfizer-BioNTech and Moderna. The vaccines, study after study has shown, are more than 90 percent effective at preventing the worst outcomes, including hospitalization and death. But alongside this good news have been rare reports of severe Covid in people who had been fully vaccinated. On June 3, for instance,…

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Why are women more prone to long Covid?

Why are women more prone to long Covid?

The Observer reports: In June 2020, as the first reports of long Covid began to filter through the medical community, doctors attempting to grapple with this mysterious malaise began to notice an unusual trend. While acute cases of Covid-19 – particularly those hospitalised with the disease – tended to be mostly male and over 50, long Covid sufferers were, by contrast, both relatively young and overwhelmingly female. Early reports of long Covid at a Paris hospital between May and July…

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Only in our anti-truth hellscape could Anthony Fauci become a supervillain

Only in our anti-truth hellscape could Anthony Fauci become a supervillain

Margaret Sullivan writes: In October, Fauci told CBS’s “60 Minutes” that he and his family had received death threats and said he required a security detail to do his daily power walks. In November, former Trump adviser Stephen K. Bannon was banned from Twitter after he called for Fauci’s beheading. But the campaign against Fauci has dramatically intensified recently — especially since BuzzFeed and The Washington Post released his email trove last week. And in a twisted way, it makes…

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The value of the Hubble Constant and the fate of the universe

The value of the Hubble Constant and the fate of the universe

Corey S Powell writes: What determines our fate? To the Stoic Greek philosophers, fate is the external product of divine will, ‘the thread of your destiny’. To transcendentalists such as Henry David Thoreau, it is an inward matter of self-determination, of ‘what a man thinks of himself’. To modern cosmologists, fate is something else entirely: a sweeping, impersonal physical process that can be boiled down into a single, momentous number known as the Hubble Constant. The Hubble Constant can be…

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The evidence still suggests the virus came from nature

The evidence still suggests the virus came from nature

Angela L. Rasmussen and Stephen A. Goldstein write: In March 2020, a group of renowned evolutionary virologists analyzed the genome sequence of SARS-CoV-2 and found it was overwhelmingly likely that this virus had never been manipulated in any laboratory. Like the earlier coronaviruses SARS-CoV and MERS-CoV, they theorized, it “spilled over” from its natural reservoir host (bats) to a new one (humans). Viruses jump species frequently, with unpredictable consequences. Often a virus hits an evolutionary dead end if it cannot…

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Fauci calls on China to release medical records of Wuhan lab researchers

Fauci calls on China to release medical records of Wuhan lab researchers

The Financial Times reports that President Biden’s chief medical adviser, Dr Anthony Fauci, has called on China to release the medical records of nine people whose illnesses might provide vital clues into whether Covid-19 first emerged as the result of a lab leak. He told the FT that the records could help resolve the debate over the origins of a disease that has killed more than 3.5 million people worldwide. The records concern three researchers at the Wuhan Institute of…

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The mRNA vaccine revolution is just beginning

The mRNA vaccine revolution is just beginning

Stephen Buranyi writes: No one expected the first Covid-19 vaccine to be as good as it was. “We were hoping for around 70 per cent, that’s a success,” says Dr Ann Falsey, a professor of medicine at the University of Rochester, New York, who ran a 150-person trial site for the Pfizer-BioNTech vaccine in 2020. Even Uğur Şahin, the co-founder and CEO of BioNTech, who had shepherded the drug from its earliest stages, had some doubts. All the preliminary laboratory…

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The lab-leak theory: Inside the fight to uncover Covid-19’s origins

The lab-leak theory: Inside the fight to uncover Covid-19’s origins

Katherine Eban writes: Gilles Demaneuf is a data scientist with the Bank of New Zealand in Auckland. He was diagnosed with Asperger’s Syndrome ten years ago, and believes it gives him a professional advantage. “I’m very good at finding patterns in data, when other people see nothing,” he says. Early last spring, as cities worldwide were shutting down to halt the spread of COVID-19, Demaneuf, 52, began reading up on the origins of SARS-CoV-2, the virus that causes the disease….

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Covid’s deadliest phase may come soon

Covid’s deadliest phase may come soon

Zeynep Tufekci writes: If world leaders don’t act now, the end of the Covid pandemic may come with a horrible form of herd immunity, as more transmissible variants that are taking hold around the world kill millions. There’s troubling new evidence that the B.1.617.2 variant, first identified in India, could be far more transmissible than even the B.1.1.7 variant, first identified in Britain, which contributed to some of the deadliest surges around the world. In countries with widespread vaccination, like…

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