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Category: Neuroscience

The neurons that appeared from nowhere

The neurons that appeared from nowhere

Nayanah Siva writes: The scientists crowded around Yuanchao Xue’s petri dish. They couldn’t identify the cells that they were seeing. “We saw a lot of cells with spikes growing out of the cell surface,” said Xiang-Dong Fu, the research team’s leader at the University of California, San Diego. “None of us really knew that much about neuroscience, and we asked around and someone said that these were neurons.” The team, who were made up of basic cellular and molecular scientists,…

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Mitochondria may hold keys to anxiety and mental health

Mitochondria may hold keys to anxiety and mental health

Elizabeth Landau writes: Carmen Sandi recalls the skepticism she faced at first. A behavioral neuroscientist at the Swiss Federal Institute of Technology in Lausanne, she had followed a hunch that something going on inside critical neural circuits could explain anxious behavior, something beyond brain cells and the synaptic connections between them. The experiments she began in 2013 showed that neurons involved in anxiety-related behaviors showed abnormalities: Their mitochondria, the organelles often described as cellular power plants, didn’t work well —…

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Love is medicine for fear

Love is medicine for fear

Arthur C. Brooks writes: We are living in a time of fear. The coronavirus pandemic has threatened our lives, health, and economy in ways most Americans have never experienced. We have no idea what the future will bring. According to the American Psychological Association’s annual “Stress in America” survey, the percentage of people in the U.S. who say that “the future of our nation is a significant source of stress” rose to 83 percent in June 2020, up from 63…

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Psychobiome: The gut bacteria that may alter how you think, feel, and act

Psychobiome: The gut bacteria that may alter how you think, feel, and act

Science reports: Katya Gavrish is searching for new brain drugs in a seemingly unlikely place: human stool samples. An earnest and focused microbiologist who trained in Russia and loves classical music, she’s standing in front of a large anaerobic chamber in a lab at Holobiome, a small startup company in Cambridge, Massachusetts. She reaches into the glass-fronted chamber through Michelin Man–like sleeves to begin to dilute the sample inside. That’s the first step toward isolating and culturing bacteria that Gavrish…

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How emotions connect your body and brain

How emotions connect your body and brain

Kevin Berger writes: Do you think you can read emotions like joy or anger in another person’s face and actions? Read them because joy and anger are universal emotions and we all know what they look and feel like? Well, if so, says neuroscientist Lisa Feldman Barrett, you are winging it, guessing at best. Emotions like happiness and despair are not baked into our brains, waiting to be triggered by experiences in the world. Sure, we have a range of…

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There is no homunculus in our brain who guides us

There is no homunculus in our brain who guides us

M.R. O’Connor writes: In the early 1980s, the psychologist Harry Heft put a 16 mm camera in the back of a sports car and made a movie. It consisted of a continuous shot of a residential neighborhood in Granville, Ohio, where Heft was a professor at Denison University. It didn’t have a plot or actors, but it did have a simple narrative: The car started moving at 5 miles per hour and made nine turns from one street to another…

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The biology of love

The biology of love

Ruth Feldman writes: After decades following thousands of mother-infant dyads, hundreds from birth to young adulthood, my lab has mapped the ‘neurobiology of affiliation’ – the emerging scientific field that describes the neural, endocrine and behavioural systems sustaining our capacity to love. The foci of our research – the oxytocin system (based on the neurohormone of bonding); the affiliative, or social, brain; and biological synchrony between mother and child – are all marked by great plasticity, and sculpted throughout animal…

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Can we describe the brain?

Can we describe the brain?

Grigori Guitchounts writes: A complete human connectome [charting the entirety of the connections among neurons in the brain] will be a monumental technical achievement. A complete wiring diagram for a mouse brain alone would take up two exabytes. That’s 2 billion gigabytes; by comparison, estimates of the data footprint of all books ever written come out to less than 100 terabytes, or 0.005 percent of a mouse brain. But [Jeff] Lichtman is not daunted. He is determined to map whole…

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Neural dendrites reveal their computational power

Neural dendrites reveal their computational power

Jordana Cepelewicz writes: The information-processing capabilities of the brain are often reported to reside in the trillions of connections that wire its neurons together. But over the past few decades, mounting research has quietly shifted some of the attention to individual neurons, which seem to shoulder much more computational responsibility than once seemed imaginable. The latest in a long line of evidence comes from scientists’ discovery of a new type of electrical signal in the upper layers of the human…

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To decode the brain, scientists automate the study of behavior

To decode the brain, scientists automate the study of behavior

Jordana Cepelewicz writes: The quest to understand what’s happening inside the minds and brains of animals has taken neuroscientists down many surprising paths: from peering directly into living brains, to controlling neurons with bursts of light, to building intricate contraptions and virtual reality environments. In 2013, it took the neurobiologist Bob Datta and his colleagues at Harvard Medical School to a Best Buy down the street from their lab. At the electronics store, they found what they needed: an Xbox…

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How microbiomes affect fear

How microbiomes affect fear

Elena Renken writes: Our brains may seem physically far removed from our guts, but in recent years, research has strongly suggested that the vast communities of microbes concentrated in our digestive tract open lines of communication between the two. The intestinal microbiome has been shown to influence cognition and emotion, affecting moods and the state of psychiatric disorders, and even information processing. But how it could do so has been elusive. Until recently, studies of the gut-brain relationship have mostly…

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Is there actually science behind ‘dopamine fasting’?

Is there actually science behind ‘dopamine fasting’?

Live Science reports: “Dopamine fasting” may be Silicon Valley’s latest wellness trend — but does this sciency-sounding fad actually have evidence to back it up? During a so-called dopamine fast, extreme practitioners abstain from any experience that brings them pleasure, including but not limited to sex, food, exercise, social media, video games and talking, according to Vox. Some people go so far as to avoid making eye contact, chatting with friends or even performing moderately-fast movements, all in an effort…

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Your brain operates on the brink of chaos

Your brain operates on the brink of chaos

Kelly Clancy writes: In one important way, the recipient of a heart transplant ignores its new organ: Its nervous system usually doesn’t rewire to communicate with it. The 40,000 neurons controlling a heart operate so perfectly, and are so self-contained, that a heart can be cut out of one body, placed into another, and continue to function perfectly, even in the absence of external control, for a decade or more. This seems necessary: The parts of our nervous system managing…

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A molecular connection between the brain and aging

A molecular connection between the brain and aging

Veronique Greenwood writes: A thousand seemingly insignificant things change as an organism ages. Beyond the obvious signs like graying hair and memory problems are myriad shifts both subtler and more consequential: Metabolic processes run less smoothly; neurons respond less swiftly; the replication of DNA grows faultier. But while bodies may seem to just gradually wear out, many researchers believe instead that aging is controlled at the cellular and biochemical level. They find evidence for this in the throng of biological…

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‘Noise’ in the brain encodes surprisingly important signals

‘Noise’ in the brain encodes surprisingly important signals

Jordana Cepelewicz writes: At every moment, neurons whisper, shout, sputter and sing, filling the brain with a dizzying cacophony of voices. Yet many of those voices don’t seem to be saying anything meaningful at all. They register as habitual echoes of noise, not signal; as static, not discourse. Since scientists first became capable of recording from single neurons 60 years ago, they’ve known that brain activity is highly variable, even when there’s no obvious reason it should be. An animal’s…

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Science as we know it can’t explain consciousness – but a revolution is coming

Science as we know it can’t explain consciousness – but a revolution is coming

MRI scan of the brain. MRIman By Philip Goff, Durham University Explaining how something as complex as consciousness can emerge from a grey, jelly-like lump of tissue in the head is arguably the greatest scientific challenge of our time. The brain is an extraordinarily complex organ, consisting of almost 100 billion cells – known as neurons – each connected to 10,000 others, yielding some ten trillion nerve connections. We have made a great deal of progress in understanding brain activity,…

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